![]() ![]() Monitor therapyĬholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Avoid combinationīCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Drug InteractionsīCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Burned area should be covered with cream at all times reapply to areas where cream has been removed by patient activity. Do not discontinue therapy if the possibility of infection exists unless a significant adverse reaction has occurred.īurn, treatment: Infants >2 months, Children, and Adolescents: Limited data available in infants and children: Topical: Apply to a thickness of 1/ 16 inch once or twice daily reapply as needed burned area should be covered with cream at all times (Caruso 2006 de Graaf 2016, Schonfeld 1990) Administrationįor topical use only avoid contact with eyes. Note: Continue use until healing has occurred or the burn site is ready for grafting. Do not discontinue therapy if the possibility of infection exists unless a significant adverse reaction has occurred. Continue use until healing has occurred or the burn site is ready for grafting. Dosage and Administration Dosing: Adultīurn treatment: Topical: Apply to a thickness of 1/ 16 inch once or twice daily reapply as needed to areas where the cream is removed by patient activity as the burned area should be covered with cream at all times. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty. Hypersensitivity to silver sulfadiazine or any component of the formulation pregnant women approaching or at term premature infants or neonates ≤2 months of age.ĭocumentation of allergenic cross-reactivity for drugs in this class is limited. Sulfadiazine: ~24 hours (Sano 1982) Use: Labeled Indicationsīurn treatment: As an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns. Silver: Feces slow excretion rate Sulfadiazine: Urine (6.6% within 5 days) (Sano 1982) Half-Life Elimination Negligible (superficial and deep burns and normal skin) increased absorption with blister removal (Sano 1982) Excretion Active against Pseudomonas aeruginosa, Pseudomonas maltophilia, Enterobacter species, Klebsiella species, Serratia species, Escherichia coli, Proteus mirabilis, Morganella morganii, Providencia rettgeri, Proteus vulgaris, Providencia species, Citrobacter species, Acinetobacter calcoaceticus, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus species, Candida albicans, Corynebacterium diphtheriae, and Clostridium perfringens Pharmacokinetics/Pharmacodynamics Absorption Bactericidal for many gram-negative and gram-positive bacteria and is effective against yeast. New York, NY: Pfizer, Inc 2016.Acts upon the bacterial cell wall and cell membrane. With a valid prescription from your doctor, you can buy Silvadene Cream 1% online at a competitive price at Canada Pharmacy. Call your doctor right away if you have side effects that bother you or won’t go away. Do not get Silvadene Cream 1% in your eyes.Ībnormal white blood cell counts, skin breakdown, skin discoloration, burning, and rash are some Silvadene Cream 1% side effects that can occur.Silvadene Cream 1% may need to be stopped in patients with liver and kidney problems.Patients with glucose-6-phosphate dehydrogenase deficiency may need to avoid Silvadene Cream 1%, as hemolysis (breakdown of red blood cells) can occur.Fungal proliferation can occur in and below the dead tissue.Patients who are allergic to sulfonamides may develop a reaction to Silvadene Cream 1%.Absorption of Silvadene Cream 1% varies based on body surface area and tissue damage.Your health conditions and past medical history. ![]() ![]() Any medications you use, including other creams, lotions, or ointments.Before you begin using Silvadene Cream 1% for burns, tell your doctor about:.Silvadene Cream 1% should not be used on pregnant women who are close to or at term, premature infants, or newborn infants. Patients who are allergic to silver sulfadiazine or to any of its other ingredients should not use the medication. Silver sulfadiazine is the active ingredient contained in Silvadene Cream 1%. Your doctor will tell you how long you should use Silvadene Cream 1%. If you have any questions or concerns, contact your doctor or pharmacy.Īpply the cream (about 1/16 inch in thickness) one to two times a day. Use Silvadene Cream 1% as directed by your doctor. ![]()
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